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Advancing the generation of in-vivo chimeric lungs in mice using rat-derived stem cells

Advancing the generation of in-vivo chimeric lungs in mice using rat-derived stem cells
medicalxpress.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from medicalxpress.com Daily Mail and Mail on Sunday newspapers.

Iiib fgfrAyako isotaniShunsuke yuriNara institute of scienceNara institute

Breakthrough in designing complicated all-α protein structures

Breakthrough in designing complicated all-α protein structures
asiaresearchnews.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from asiaresearchnews.com Daily Mail and Mail on Sunday newspapers.

Japan generalNaohiro kobayashiToshio nagashimaToshihiko sugikiTakahiro kosugiToshimichi fujiwaraKoya sakumaNaoya kobayashiTakeshi murataNobuyasu kogaInstitute for molecular scienceExploratory research center on lifeNagoya universityProtein data bankNational institutes of natural sciencesInstitute for protein research

First observation of structures resulting from 3D domain swapping in antibody light chains

First observation of structures resulting from 3D domain swapping in antibody light chains
sciencedaily.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from sciencedaily.com Daily Mail and Mail on Sunday newspapers.

Nara institute of scienceNature communicationsShun hirotaNara institute

Novel insights into antibody aggregation expected to open up new avenues for research and therapeutic applications

Novel insights into antibody aggregation expected to open up new avenues for research and therapeutic applications
phys.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from phys.org Daily Mail and Mail on Sunday newspapers.

Takahiro sakaiNature communicationsNara institute of scienceShun hirotaNara instituteThermodynamic insightsAntibody light chain tetramer formationDomain swapping

First observation of structures resulting fro

<p style="text-align:justify">Antibodies hold promise as therapeutic agents. However, their tendency to aggregate poses significant challenges to drug development. In a groundbreaking study, researchers from Japan now provide novel insights into the structure formed due to 3D domain swapping of the antibody light chain, the part of the antibody contributing to antigen binding. Their findings are expected to lead to improvements in antibody quality and the development of novel drugs.</p>

Japan generalKowit hengphasatpornYasuteru shigetaTakahiro sakaiEmi hifumiHideaki ogataRyo fujikiTsuyoshi mashimaNaoya kobayashiTaizo udaSupramolecular chemistry labNara institute of scienceNature communicationsShun hirotaNara instituteThermodynamic insights