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Novel insights into antibody aggregation expected to open up new avenues for research and therapeutic applications

Novel insights into antibody aggregation expected to open up new avenues for research and therapeutic applications
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Takahiro sakaiNature communicationsNara institute of scienceShun hirotaNara instituteThermodynamic insightsAntibody light chain tetramer formationDomain swapping

First observation of structures resulting fro

<p style="text-align:justify">Antibodies hold promise as therapeutic agents. However, their tendency to aggregate poses significant challenges to drug development. In a groundbreaking study, researchers from Japan now provide novel insights into the structure formed due to 3D domain swapping of the antibody light chain, the part of the antibody contributing to antigen binding. Their findings are expected to lead to improvements in antibody quality and the development of novel drugs.</p>

Japan generalKowit hengphasatpornYasuteru shigetaTakahiro sakaiEmi hifumiHideaki ogataRyo fujikiTsuyoshi mashimaNaoya kobayashiTaizo udaSupramolecular chemistry labNara institute of scienceNature communicationsShun hirotaNara instituteThermodynamic insights