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Editor s Note: This story was updated at 4:00 pm CST, adding in the second, unpublished, study.
SARS-CoV-2 antibodies transferred across the placenta in 87% of pregnant women who had COVID-19 at some point, suggesting that newborns of seropositive mothers may have some protection against the novel coronavirus at birth, according to a study today in
JAMA Pediatrics. However, a second, unpublished study suggests that the maternal-infant antibody transfer is lower than expected.
IgG but not IgM in cord blood
In the first study, a team led by researchers from Children s Hospital of Philadelphia collected discarded maternal and cord blood sera from 1,471 mother-newborn pairs with available sera for measurement of anti-spike protein immunoglobulin G (IgG) and immunoglobulin M (IgM) at Pennsylvania Hospital from Apr 9 to Aug 8.
Embarazo y Covid-19: ¿cuál es el riesgo para la madre? ¿y para el feto? ¿qué ocurre con los anticuerpos? infobae.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from infobae.com Daily Mail and Mail on Sunday newspapers.
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Mothers with COVID-19 produced a robust antibody response, but transfer of antibodies across the placenta to their infants was less efficient than expected, researchers found.
In an analysis of pregnant women who had COVID-19, neutralizing activity which measures the potency of antibody response was detected in 94% of maternal blood samples and only 25% of cord blood, according to Naima Joseph, MD, MPH, of Emory University in Atlanta, and colleagues.
The overall cord-to-maternal anti-receptor binding (RBD) immunoglobulin (Ig)G ratio was 81%, Joseph reported at the Society for Maternal-Fetal Medicine annual meeting. There is a maternal antibody response that is robust following infection, Joseph said in her presentation. But while she emphasized that anti-RBD domain IgG titers were detected in umbilical cord samples, she said it was unexpected that the efficiency of transfer was less than 1.
The U.S. new cases 7-day rolling average are 15.7 % LOWER than the 7-day rolling average one week ago. U.S. hospitalizations due to COVID-19 are now 10.0 %
LOWER than the rolling average one week ago. U.S. deaths due to coronavirus are now 5.4 %
HIGHER than the rolling average one week ago. Today s posts include:
U.S. Coronavirus New Cases are 168,620
U.S. Coronavirus hospitalizations are at an elevated 104,303
U.S. Coronavirus deaths are at an elevated 4,000
U.S. Coronavirus immunizations have been administered to 7.9 % of the population
The 7-day rolling average rate of growth of the pandemic shows new cases worsened, hospitalizations improved, and deaths improved
Maternal COVID Antibodies Cross Placenta, Detected in Newborns medscape.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from medscape.com Daily Mail and Mail on Sunday newspapers.