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Percentage of Heavy Drinking Days Following Psilocybin-Assisted Psychotherapy vs Placebo in the Treatment of Adult Patients With Alcohol Use Disorder: A Randomized Clinical Trial | Psychiatry and Behavioral Health | JAMA Psychiatry

This randomized clinical trial evaluates the combination of psychotherapy with psilocybin vs active placebo in patients with alcohol use disorder.

United statesNew yorkPurdue universityWest lafayetteNew york universityNew mexicoUniversity of new mexicoCeruvia lifesciencesDavid nicholsNicholas cozziMichaelp bogenschutzClaudia turnbullNational institute on drug abuseHealth connectionsB more incDavid nichols at purdue university

Reproductive factors and the risk of incident dementia: A cohort study of UK Biobank participants

In a cohort study, Jessica Gong and colleagues investigate associations between reproductive factors, number of children, and dementia among individuals in the UK Biobank.

New south walesUnited kingdomUnited statesSouth koreaKaiser permanenteCarol brayneResearch ethics committeeRstudio teamUnited kingdom biobank outcome adjudication groupAustralian national healthInternational consortiumProgram grantResearch tissue bankStata statistical softwareResearch council investigator grantUniversity of cambridge

Temporal changes in factors associated with COVID-19 vaccine hesitancy and uptake among adults in Hong Kong: Serial cross-sectional surveys

Temporal changes in factors associated with COVID-19 vaccine hesitancy and uptake among adults in Hong Kong: Serial cross-sectional surveys
thelancet.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from thelancet.com Daily Mail and Mail on Sunday newspapers.

Hong kongUniversity of hong kongHong kong generalSanofi pasteurHealth bureau of the hong kongWorld health organizationCentre for health protectionHong kong centre for health protectionLancet groupUniversity of hong kong reference noResearch fundR foundation for statistical computingMedical research fundWorld healthCantonese speaking hong kongInfect dis

The effect of inhaled hypertonic saline on lung structure in children aged 3–6 years with cystic fibrosis (SHIP-CT): a multicentre, randomised, double-blind, controlled trial

The effect of inhaled hypertonic saline on lung structure in children aged 3–6 years with cystic fibrosis (SHIP-CT): a multicentre, randomised, double-blind, controlled trial
thelancet.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from thelancet.com Daily Mail and Mail on Sunday newspapers.

United kingdomDanielle samulskiPediatr pulmonolJ stat softwareRespir medCyst fibrosDatabase syst revEnglj medParent cystic fibrosis questionnaireMultivariate imputationChained equationsStat softwareInterdiscip rev comput statOpen res

Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19

Abstract While it is now widely accepted that host inflammatory responses contribute to lung injury, the pathways that drive severity and distinguish coronavirus disease 2019 (COVID-19) from other viral lung diseases remain poorly characterized. We analyzed plasma samples from 471 hospitalized patients recruited through the prospective multicenter ISARIC4C study and 39 outpatients with mild disease, enabling extensive characterization of responses across a full spectrum of COVID-19 severity. Progressive elevation of levels of numerous inflammatory cytokines and chemokines (including IL-6, CXCL10, and GM-CSF) were associated with severity and accompanied by elevated markers of endothelial injury and thrombosis. Principal component and network analyses demonstrated central roles for IL-6 and GM-CSF in COVID-19 pathogenesis. Comparing these profiles to archived samples from patients with fatal influenza, IL-6 was equally elevated in both conditions whereas GM-CSF was prominent only in

United kingdomUnited statesCity ofLa jollaOxford immunotechJeremyj farrarQuanterix billericaNahoko shindoMilliporesigma burlingtonEthics review committeeImperial biomedical research centreScotlanda research ethics committee refOxfordc research ethics committeeMaterial access committeeZoonotic infections at university of liverpoolHealth protection research unit

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