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Discontinuation versus continuation of hypertonic saline or dornase alfa in modulator treated people with cystic fibrosis (SIMPLIFY): results from two parallel, multicentre, open-label, randomised, controlled, non-inferiority trials

In individuals with cystic fibrosis on ETI with relatively well preserved pulmonary function, discontinuing daily hypertonic saline or dornase alfa for 6 weeks did not result in clinically meaningful differences in pulmonary function when compared with continuing treatment.

United kingdomUnited statesPediatr pulmonolDanielle samulskiMogayzel jrCystic fibrosis foundationRespir crit care medEnglj medCyst fibrosMed internet resAfrican americanCystic fibrosis questionnaire revisedLife resFibrosis foundationRespir med

The effect of azithromycin on structural lung disease in infants with cystic fibrosis (COMBAT CF): a phase 3, randomised, double-blind, placebo-controlled clinical trial

The effect of azithromycin on structural lung disease in infants with cystic fibrosis (COMBAT CF): a phase 3, randomised, double-blind, placebo-controlled clinical trial
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United statesEsther jrPediatr pulmonolJ clin pharmacolInstitute for clinicalTransl medEnglj medCyst fibrosPharmacol therDatabase syst revRespir medEconomic reviewOpin pediatr

The effect of inhaled hypertonic saline on lung structure in children aged 3–6 years with cystic fibrosis (SHIP-CT): a multicentre, randomised, double-blind, controlled trial

The effect of inhaled hypertonic saline on lung structure in children aged 3–6 years with cystic fibrosis (SHIP-CT): a multicentre, randomised, double-blind, controlled trial
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United kingdomDanielle samulskiPediatr pulmonolJ stat softwareRespir medCyst fibrosDatabase syst revEnglj medParent cystic fibrosis questionnaireMultivariate imputationChained equationsStat softwareInterdiscip rev comput statOpen res

Santhera Announces Positive Results with Lonodelestat in Early Phase Cystic Fibrosis Trial

Santhera Announces Positive Results with Lonodelestat in Early Phase Cystic Fibrosis Trial
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Switzerland generalUnited statesSellier kesslerEva kaliasPharma gmbDario eklundSanthera pharmaceuticalsHead external communicationsChiesi groupHead of department pediatric respiratory medicineCystic fibrosis foundationSanthera pharmaceuticals holdingMarcus mallPediatric respiratory medicineCritical care medicineCyst fibros

Neutrophil extracellular traps, disease severity, and antibiotic response in bronchiectasis: an international, observational, multicohort study

Neutrophil extracellular traps, disease severity, and antibiotic response in bronchiectasis: an international, observational, multicohort study
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United kingdomMccray jrNat protocEuropean respiratory societyLancet glob healthResearch network of india registryResearch collaborationRespir medEuropean multicentre bronchiectasis auditRespiratory research networkGlob healthRespiratory societyCyst fibrosInnate immunClin investEnglj med