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Research provides first evidence for a possible cause of familial ALS

Amyotrophic lateral sclerosis (ALS) is a degenerative disease. The neurons responsible for movement begin to die and muscle control is progressively lost, leading to a fatal outcome.

Oleksandra sirozhVanesa lafargaFernandez capetilloFrancisco luzMinistry of scienceGenomic instability groupSpanish national cancer research centerCaixa foundationSpanish association against cancerEuropean unionNacional de investigaciones oncolMolecular cellAmyotrophic lateral sclerosisDegenerative diseaseMotor neurons

Study proposes novel approach to slow neuromuscular degeneration in ALS patients

A study led by the Center for Biomaterials and Tissue Engineering of the Universitat Politècnica de València, member of Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine, in collaboration with the Instituto de Investigación Sanitaria La Fe and the University of Zaragoza proposes a novel approach to slow neuromuscular degeneration in patients with Amyotrophic Lateral Sclerosis.

Fran ferrerJuan franciscoEduardo rubioSant cristResearch group in neuromuscular pathologyBiomedical research networking centerStopela associationUniversity of zaragoza unizarStopela patient associationTissue engineeringUniversitat politInstituto de investigaciAmyotrophic lateral sclerosisPatricia ricoMotor neuron diseases unitHospital universitari

New drug targets key mechanism in ALS, protects motor neurons

A new pharmacological inhibitor can intervene in a central cell death mechanism that is responsible for the death of motor neurons and hence important for the progression of the motor neuron disease amyotrophic lateral sclerosis (ALS).

Baden wübergHilmar badingJing yanDepartment of neurobiologyInterdisciplinary centerEuropean research councilHeidelberg universityGerman research foundationAlexander von humboldt foundationFundamental pharmaAmyotrophic lateral sclerosisEll deathDegenerative diseaseMotor neuron diseaseMotor neuronsOuse model

ALS progression linked to mitochondria-associated membrane-ER disconnection

Researchers at Nagoya University in Japan have discovered a relationship between the progression of amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, and the disruption of mitochondria-associated membranes (MAM), the contact point between the mitochondria and the endoplasmic reticulum (ER) of the cell.

Lou gehrigSeiji watanabeMasahisa katsunoSchool of medicineProceedings of the national academy sciencesResearchers at nagoya universityNagoya universityNational academyKoji yamanakaResearch instituteEnvironmental medicineGraduate schoolAmyotrophic lateral sclerosisLou gehrig 39s diseaseMotor neurons

Webinar: Empowering motor neuron disease research and drug discovery with a new class of functional, reproducible hiPSC-derived motor neurons

Webinar: Empowering motor neuron disease research and drug discovery with a new class of functional, reproducible hiPSC-derived motor neurons
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Tom brownMarcos herrera vaqueroSenior scientistSenior product managerMotor neurons