Roska group researchers find: When unconscious, the brain is anything but silent streetinsider.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from streetinsider.com Daily Mail and Mail on Sunday newspapers.
The loss of inner ear hair cells causes permanent hearing and balance deficits in humans and other mammals, but nonmammals recover after supporting cells (SCs) divide and replace hair cells. The proliferative capacity of mammalian SCs declines as exceptionally thick circumferential F-actin bands develop at their adherens junctions. We hypothesized that the reinforced junctions were limiting regenerative responses of mammalian SCs by impeding changes in cell shape and epithelial tension. Using micropipette aspiration and atomic force microscopy, we measured mechanical properties of utricles from mice and chickens. Our data show that the epithelial surface of the mouse utricle stiffens significantly during postnatal maturation. This stiffening correlates with and is dependent on the postnatal accumulation of F-actin and the cross-linker Alpha-Actinin-4 at SC-SC junctions. In chicken utricles, where SCs lack junctional reinforcement, the epithelial surface remains compliant. There, SCs un
Protective antibodies elicited by SARS-CoV-2 spike protein vaccination are boosted in the lung after challenge in nonhuman primates science.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from science.org Daily Mail and Mail on Sunday newspapers.
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1118. (
B) Heatmap of the expression of TSC genes averaged across 2 days of observation. The presence of the characteristic circadian patterns in the tissue is indicated with black rectangles around the heatmaps. The number at the left designates the number of detected TSC genes. (
C and
D) Heatmap of cycling in two (C) and three tissues (D) gene expression averaged across 2 days of observation. Black rectangles indicate tissues in which genes were found to be cycling. For (B) to (D), lighter areas or the heatmaps correspond to lower expression levels. The time is indicated at the bottom of the heatmap. (