Using a new approach for studying live embryonic mouse brains at single-cell resolution, researchers have identified an active multi-layer circuit that forms in the cortex during an unexpectedly early stage of development. Perturbing the circuit genetically led to changes similar to those seen in the brains of people with autism. The findings are reported today in Cell by a team based at the Institute of Molecular and Clinical Ophthalmology Basel.
In a paper recently published in Neuron, researchers from the group of Botond Roska at IOB reveal how different cell types in cortex change their activity during general anesthesia, helping to understand how unconsciousness may be induced.