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Research Reveals Gene Expression Alterations Can Trigger Autism

Research Reveals Gene Expression Alterations Can Trigger Autism
miragenews.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from miragenews.com Daily Mail and Mail on Sunday newspapers.

Japan generalTakaoki kasaharaAtsushi takataTakumi nakamuraKurara hondaJunko uedaToru takumiMasahide asanoMoe nakanishiShigeyoshi itoharaTomonori haraTadafumi katoMitsutaka kadotaChiharu tanegashimaTakashi tsuboiShigehiro kuraku

New study uncovers how altered gene expressio

The loss-of-function mutation of KMT2C, a gene involved in histone modification, leads to the development of autism and other neurodevelopmental deficits. However, the precise mechanism of the disease progression is still unknown. Now, researchers from Japan have developed an animal model and elucidated the mechanism by which mutation in genes involved in chromatin modification causes autism. They have also discovered a drug that can be used in the treatment of autism.

Japan generalShigehiro kurakuTadafumi katoKurara hondaTakumi nakamuraAtsushi takataJunko uedaTakashi tsuboiMizuho ishiwataToru takumiTomonori haraShigeyoshi itoharaToru yoshiharaTakaoki kasaharaChiharu tanegashimaYuki kobayashi

New study uncovers how altered gene expressio

New study uncovers how altered gene expressio
eurekalert.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from eurekalert.org Daily Mail and Mail on Sunday newspapers.

Japan generalTakumi nakamuraShigehiro kurakuKurara hondaTadafumi katoTomonori haraAtsushi takataSumitomo dainippon pharmaTakaoki kasaharaMoe nakanishiToru takumiToru yoshiharaYuki kobayashiShigeyoshi itoharaMizuho ishiwataTakashi tsuboi

Patchwork of Mutations Contribute to Bipolar Disorder

Patchwork of Mutations Contribute to Bipolar Disorder
miragenews.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from miragenews.com Daily Mail and Mail on Sunday newspapers.

Japan generalAtsushi takataMizuho ishiwataTakashi hayamaShinichi kuriyamaMasaki nishiokaKumiko fujiiJun takayamaTadafumi katoJunko uedaToshiyuki someyaGen tamiyaNaomi sakaiStatistical genetics teamDepartment of psychiatryDepartment of molecular pathology mood disorders

Patchwork of mutations contributing to bipola

Bipolar disorder (BD) is a serious psychiatric disorder affecting around 1% of the population worldwide. While medications are indispensable for these patients, they are not completely effective, and the underlying genetic architecture and pathogenesis of BD remain unresolved. Researchers from Japan have now used deep exome sequencing to show that mosaic variants/mutations found in genes related to developmental disorders and autism spectrum disease and in the mitochondrial tRNA region could be associated with BD.

Japan generalJun takayamaTadafumi katoGen tamiyaMizuho ishiwataAtsushi takataTakashi hayamaNaomi sakaiJunko uedaMasaki nishiokaToshiyuki someyaShinichi kuriyamaKumiko fujiiDepartment of molecular epidemiologyTohoku university school of medicineLaboratory for molecular pathology of psychiatric disorders