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Patchwork of Mutations Contribute to Bipolar Disorder

Patchwork of Mutations Contribute to Bipolar Disorder
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Research sheds new light on the genetic architecture of bipolar disorder

Bipolar disorder (BD) is a major psychiatric condition that afflicts about 1% of people. Symptoms of BD include sudden onset of depressive mood with loss of interest which alternates with a manic state of hyperactivity.

Unraveling the Quirky Genetics of Bipolar Disorder

Bipolar disorder (BD) is a significant psychiatric condition that affects approximately 1% of the population. It is characterized by alternating episodes

Patchwork of mutations contributing to bipola

Bipolar disorder (BD) is a serious psychiatric disorder affecting around 1% of the population worldwide. While medications are indispensable for these patients, they are not completely effective, and the underlying genetic architecture and pathogenesis of BD remain unresolved. Researchers from Japan have now used deep exome sequencing to show that mosaic variants/mutations found in genes related to developmental disorders and autism spectrum disease and in the mitochondrial tRNA region could be associated with BD.

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