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Using next-gen CRISPR tool, Gladstone scienti

<p>In a study of historic scale, scientists at Gladstone Institutes have created an intricate map of how the immune system functions, examining the detailed molecular structures governing human T cells using the next-generation CRISPR tool known as base editing. Their findings, published in <em>Nature</em>, uncover detailed information that could help overcome the limitations of today’s immunotherapies and identify new drug targets for a wide range of diseases, including autoimmune diseases and cancer. </p>

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How Unique Immune Cells Can Recognize--and Destroy--Tumors

/PRNewswire/ Gamma delta T cells, a special type of cell in the immune system, are incredibly effective at recognizing and killing cancer cells. Cancer.

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How Unique Immune Cells Can Recognize--and Destroy--Tumors

How Unique Immune Cells Can Recognize--and Destroy--Tumors
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How Unique Immune Cells Can Recognize--and Destroy--Tumors

How Unique Immune Cells Can Recognize--and Destroy--Tumors
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Resource Links Gene Variants with Immune System Regulation and Immune-Mediated Diseases

Resource Links Gene Variants with Immune System Regulation and Immune-Mediated Diseases April 30, 2021 University of Tokyo researchers and colleagues at the RIKEN Research Institute have compiled a first-of-its-kind genetic database for autoimmune and autoinflammatory diseases. It’s hoped that the resource will offer up new insights into how immune disorders develop, and potentially aid in drug discovery. Scientists also hope that the atlas of immune-related genome data may eventually be applied to investigations of infectious diseases, such as COVID-19. “To understand diseases, a deep comprehension of the function of genetic variants is essential,” said University of Tokyo project research associate Mineto Ota, MD, PhD, a clinical rheumatologist and expert in functional genomics. “With this data set, we can connect the data about changes to DNA sequence associated with a disease to genes and cell types that are important for disease pathogenesis.” Ota is lead author of

Mineto otaUniversity of tokyo immunexResearch instituteUniversity of tokyoImmune cell gene expression atlasEast asianஆராய்ச்சி நிறுவனம்பல்கலைக்கழகம் ஆஃப் டோக்கியோகிழக்கு ஆசிய