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The Impact of Regression to the Mean in Psychiatric Drug Studies

Could the statistical phenomenon of regression to the mean be responsible for the dramatic effects of placebo in psychiatric drug studies?

Sarah lazarovicMichaelp hengartnerZurich university of applied sciencesZurich universityApplied sciencesPublished online firstPlacebo effectRegression to the meanResearch methodsSpontaneous remission

Researchers Set the Record Straight on Controversial Zoloft Study

An issue of Lancet Psychiatry is devoted to clarifying the lack of efficacy for Zoloft (sertraline).

New zealandGlyn lewisMichaelp hengartnerGemma lewisKlaus munkholmZurich university of applied sciencesNordic cochrane centerUniversity of aucklandLancet psychiatryZurich universityApplied sciencesAsger sand paludan mNordic cochraneBruce arrollDepression treatmentLancet psychiatry

New Study Concludes that Antidepressants are Largely Ineffective and Potentially Harmful

A new study published in Frontiers in Psychiatry concludes that “antidepressants are largely ineffective and potentially harmful.”

Wikimedia commonsMichaelp hengartnerNational institute of mental healthZurich university of applied sciencesZurich universityApplied sciencesHamilton depressionNational instituteMental healthAntidepresant researchNtidepressant metaanalysisNtidepressants risk benefitMore harm than goodPharmaceutical industry

Unblinding in Antidepressant Trials Biases Results

Studies that compare the effectiveness of different antidepressant drugs are unreliable, according to new research in BMC Psychiatry.

Michaelp hengartnerHolperl hengartnerLisa holperZurich university of applied sciencesUniversity of zurichZurich universityAntidepressant efficacyAntidepressants and placeboLacebo efficacyPlacebo response

New Analysis: Antidepressants Still Linked to Suicide

“This is remarkable for drugs that are used to treat depressive symptoms,” write the researchers.

Michaelp hengartnerJakob andrTom bschorAffective disordersAdverse effectsAntidepressants and suicide

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