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OncLive s April Roundup of Key FDA Decisions in Oncology

OncLive s April Roundup of Key FDA Decisions in Oncology
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United statesBaylor universityNew yorkPp keiichi fujiwaraLos angelesRonanj kellyBrendonm stilesJessicas doningtonAlectinib joinsKarim chamieP saadz usmaniWw caruth jrSarahe learyTheodorew laetschUniversity of californiaUniversity of texas md anderson cancer center

TIVDAK® (tisotumab vedotin-tftv) Receives U S FDA Approval to Treat Recurrent or Metastatic Cervical Cancer

TIVDAK® (tisotumab vedotin-tftv) Receives U S FDA Approval to Treat Recurrent or Metastatic Cervical Cancer
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Miami beachNew jerseyUnited statesAndrew carlsenMarisol peronBrian slomovitzChris boshoffTamika felderEuropean society of medical oncologyGynecologic oncology groupAmerican cancer societyNational cancer instituteGlobal communications corporate affairsCervivor incCompany announcementPfizer inc

Pembrolizumab enhances progression-free survival in patients with locally advanced cervical cancer

1. Progression-free survival at 24 months was higher in the pembrolizumab versus placebo-controlled group. 2. The pembrolizumab-chemoradiotherapy group reported slightly higher rates of grade 3 or higher adverse events compared to the placebo-chemoradiotherapy group. Evidence Rating Level: 1 (Excellent) Study Rundown: Pembrolizumab has demonstrated efficacy in advanced cervical cancer, prompting an investigation into its potential

Rating levelResponse evaluation criteriaSolid tumoursMetastatic cervicalBetween junCervical cancerGynecologic oncologyLocally advanced cervical cancerChronic disease

#VisualAbstract: Atezolizumab in addition to bevacizumab and platinum-based chemotherapy improves survival in metastatic cervical cancer

1. The Atezolizumab group demonstrated significantly greater progression-free and overall survival among patients with metastatic, persistent, or recurrent cervical cancer. 2. Grade 3 or worse adverse events were comparable in both groups. Evidence Rating Level: 1 (Excellent) Study Rundown: A previous large-scale trial has shown improved overall survival among patients with cervical cancer treated with bevacizumab and

Minute medicine incRating levelMetastatic cervicalCervical cancerPlatinum based chemotherapyRecurrent cervical cancer

Atezolizumab in addition to bevacizumab and platinum-based chemotherapy improves survival in metastatic cervical cancer

1. The Atezolizumab group demonstrated significantly greater progression-free and overall survival among patients with metastatic, persistent, or recurrent cervical cancer. 2. Grade 3 or worse adverse events were comparable in both groups. Evidence Rating Level: 1 (Excellent) Study Rundown: A previous large-scale trial has shown improved overall survival among patients with cervical cancer treated with

United statesRating levelMetastatic cervicalBetween octCervical cancerImmune checkpoint inhibitorsMetastatic cervical cancerPd l1Platinum based chemotherapyChronic disease