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Agonists of the β2-adrenergic receptor (β2AR) are used as bronchodilators to relieve airway obstruction in patients with asthma. However, these drugs are much less effective in patients with airway obstruction caused by infection with respiratory syncytial virus (RSV). Harford et al . found that infection of human airway smooth muscle cells with RSV resulted in phosphorylation of the β2AR, its loss from the plasma membrane, and its proteasomal cleavage. Furthermore, RSV infection resulted in increased Ca2+ signaling in these cells, promoting their contractility in vitro. These results suggest that dysregulation of the location, abundance, and function of the β2AR by RSV may underlie the ineffectiveness of β2AR agonists in relieving airway obstruction in infected patients. Pharmacologic agonism of the β2-adrenergic receptor (β2AR) induces bronchodilation by activating the enzyme adenylyl cyclase to generate cyclic adenosine monophosphate (cAMP). β2AR agonists are generally the

United statesDepartment of cardiovascularMetabolic sciencesLerner research instituteCleveland clinic foundationஒன்றுபட்டது மாநிலங்களில்துறை ஆஃப் இருதயவளர்சிதை மாற்ற அறிவியல்லெர்னர் ஆராய்ச்சி நிறுவனம்கிளீவ்லேண்ட் சிகிச்சையகம் அடித்தளம்