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 E-Mail IMAGE: The T cell (yellow) touches the antigen-presenting cell. Tiny forces are applied on the surface, eventually the connection breaks. view more  Credit: TU Wien / MedUni Wien T-cells play a central role in our immune system: by means of their so-called T-cell receptors (TCR) they make out dangerous invaders or cancer cells in the body and then trigger an immune reaction. On a molecular level, this recognition process is still not sufficiently understood. Intriguing observations have now been made by an interdisciplinary Viennese team of immunologists, biochemists and biophysicists. In a joint project funded by the Vienna Science and Technology Fund and the FWF, they investigated which mechanical processes take place when an antigen is recognized: As T cells move their TCRs pull on the antigen with a tiny force - about five pico-newtons (5 x 10-12 or 0.0000000005 newtons). This is not only sufficient to break the bonds between the TCRs and the antigen, it a

Angewandte immunologieTechnische universitFlorian kellnerMedizinische universitJohannes huppaAngewandte physikLukas schranglNature communicationsTechnology fundVienna scienceGerhard schMeduni viennaBiomechanics biophysicsCell biologyMedicine healthImmunology allergies asthma