Researchers develop materials for oral delivery of insulin medication
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A revolutionary technology developed within the Trabolsi Research Group at NYU Abu Dhabi (NYUAD) could dramatically improve the wellbeing of diabetic patients: an insulin oral delivery system that could replace traditional subcutaneous injections without the side effects caused by frequent injections.
Using prepared layers of nanosheets with insulin loaded in between layers to protect it, the researchers developed gastro-resistant imine-linked-covalent organic framework nanoparticles (nCOFs) that exhibited insulin protection in the stomach as well in diabetic test subjects whose sugar levels completely returned to normal within two hours after swallowing the nanoparticles. Led by NYUAD s Research Scientist Farah Benyettou and Program Head of Chemistry Ali Trabolsi, the findings were published today in Chemical Science.
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