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1Department of Respiratory Medicine, People’s Hospital of Ningxia Hui Autonomous Region, Yinchuan, People’s Republic of China;
2Department of Respiratory Medicine, First Affiliated Hospital of Northwest Minzu University, Yinchuan, People’s Republic of China;
3Department of Intervention and Vascular Surgery, People’s Hospital of Ningxia Hui Autonomous, Yinchuan, People’s Republic of China;
4Department of Intervention and Vascular Surgery, First Affiliated Hospital of Northwest Minzu University, Yinchuan, People’s Republic of China These authors contributed equally to this work
Correspondence: Bing Zhuan
Department of Respiratory Medicine, First Affiliated Hospital of Northwest Minzu University, No. 301 Zhengyuan North Street, Jinfeng District, Yinchuan, 750004, People’s Republic of China
7,8 and organ protection from ischemia/reperfusion injury.
9,10 Newly synthesized transition metal carbonyl-compounds, CO release molecules (CORMs), are effective in regulating CO release in vivo and in vitro in appropriate circumstances.
11 These CO releasing molecules can therefore be used as the new carrier to provide exogenous CO. CORM-3 [tricarbonylchloro (glycinato) ruthenium (II)] is completely soluble in water with fast release of CO when dissolved in a physiological solution.
By releasing CO, CORMs also induce an anti-inflammatory effect. Our previous study showed that CORM-2 reduced periodontal inflammation and alveolar bone resorption in rats with experimental periodontitis.
13 We also reported CORM-3 suppressed the expression of adhesion molecules in human gingival fibroblasts co-stimulated by tumor necrosis factor-α and interleukin-1 β,
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