Microvessel Density is Increased in Human GC Tissues
To confirm the association between Nrf2/HO-1 and angiogenesis in GC, we also determined the microvessel density of these human GC samples. Consistently, the microvessel density was low in paracancerous tissues, but high in GC. Moreover, the microvessel density was low, moderate, and high in well-, moderately-, and poorly differentiated GC, respectively (Figure 8). Collectively, the Nrf2/HO-1 axis is likely to participate in the malignant process of GC by affecting angiogenesis.
Figure 8 The microvessel density increased in human GC. Immunohistological staining of CD34 was used to determine the microvessel density in paracancerous tissue, well-differentiated GC, and poorly differentiated GC. (