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Modest Effects, Safety Concerns Plague Vupanorsen in TRANSLATE-TIMI 70

Researchers hold little hope for this compound, which had a poor safety profile, but suggest the ANGPTL3 story isn’t over.

United statesPamela morrisBrian bergmarkMichael blahaMd medical university of south carolinaMd johns hopkins university medical centerIonis pharmaceuticalsJohns hopkins university medical centerMedical universitySouth carolina

APOLLO: Novel siRNA Injectable Cuts Lp(a) by Nearly 100% in Small Study

Lp(a), called the holy grail of prevention research, was reduced dramatically with SLN360 and should spur further research.

San diegoUnited statesAnthony demariaMichael blahaVera bittnerSteven nissenPelacarsen novartisAmerican college of cardiologyOther agents in developmentMd university of californiaMd johns hopkins university medical centerMd university of alabama at birminghamCleveland clinicAmerican collegeJohns hopkins university medical centerSilence therapeutics

PACMAN-AMI: Positive Plaque Changes With Early Alirocumab Use in Acute MI

The trial is important in helping to understand how lipid-lowering therapy improves outcomes, Michael Blaha says.

United statesSan diegoLa jollaSanofi regeneronP anthony demariaAnthony demariaMichael blahaMd uc san diego healthPhd bern university hospitalAmerican college of cardiologyMd johns hopkins university medical centerBern university hospitalAmerican collegeJohns hopkins university medical centerDiego health

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