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Two siRNA Therapeutics Safely Lower Triglycerides in Mixed Hyperlipidemia

Two siRNA Therapeutics Safely Lower Triglycerides in Mixed Hyperlipidemia
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United statesNew yorkBaylor college of medicinePradeep natarajanBrian bergmarkRobert rosensonChristie ballantyneMd baylor college of medicineIonis pharmaceuticalsArrowhead pharmaceuticalsEuropean atherosclerosis societyKowa pharmaceuticalsNew england journalBaylor collegeIcahn schoolMount sinai

New Drug Cuts Blood Triglyceride Levels in Half

New Drug Cuts Blood Triglyceride Levels in Half
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Brian bergmarkAmerican college of cardiologyWomen hospital division of cardiovascular medicineHarvard medical schoolNew england journalAmerican collegeHospital divisionHarvard medical

Triglyceride-Lowering Therapies Provide Favorable Outcomes in Early Testing

In Bridge-TIMI 73a and SHASTA-2, the RNA-silencing therapies cut triglycerides quickly, offering hope for hard-to-treat patients.

University of pennsylvaniaUnited statesWestern australiaDaniel sofferBrian bergmarkDaniel gaudetGerald wattsNeha pagidipatiPradeep natarajanPhd university of western australiaPhd university of montrealMd duke university school of medicineIonis pharmaceuticalsMd university of pennsylvania school medicineArrowhead pharmaceuticalsDrug administration

New Drug Could Slash Blood Triglyceride Levels

New Drug Could Slash Blood Triglyceride Levels
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Davido carterDennis thompson healthdayLos angelesBrian bergmarkWomen hospital division of cardiovascular medicineAmerican college of cardiologyHarvard medical schoolHealthday newsNew england journalAmerican collegeSkid rowJudge davidGetty imagesHospital divisionHarvard medicalMedical school

Early Olezarsen Results Show 50% Reduction in Triglycerides

A drug targeting mRNA essential for APO C-III production provided a 50% reduction in triglycerides in BRIDGE-TIMI 73a, the largest ever observed in a controlled trial.

United statesNorth carolinaDaniel sofferBrian bergmarkNehaj pagidipatiNational lipid associationAmerican college of cardiologyDuke clinical research instituteDuke school of medicineAmerican collegeScientific sessionNew englandMajor subgroup failedNorth americaPenn medicineNational lipid