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King s College London researchers have found evidence that minocycline, a widely used antibiotic with anti-inflammatory properties, gave greater improvement in depressive symptoms in patients with treatment resistant depression with low-grade peripheral inflammation.
Improvement in depressive symptoms
In a four-week randomised clinical MINDEP (MINocycline in DEPression) trial, 39 patients with major depressive disorder were recruited from services linked to South London and Maudsley NHS Foundation Trust (SLaM) and via public advertisement.
The trial took place at the NIHR / Wellcome Trust King s Clinical Research Facility at King s College Hospital. The patients, who were taking their routine antidepressant treatment, were split into two groups, one group took daily a placebo (sugar pill) tablet while the other group took daily minocycline alongside their routine treatment for 4 weeks.
Antibiotic may improve depressive symptoms in people with low-level inflammation: Study ANI | Updated: Jan 28, 2021 11:29 IST
Washington [US], January 28 (ANI): While antibiotics are widely used to treat bacterial infections and other illnesses, a new research suggested that minocycline, an antibiotic with anti-inflammatory properties, improved depressive symptoms in patients with low-grade peripheral inflammation.
The findings of the study were published in the journal Neuropsychopharmacology . According to the study led by King s College London researchers minocycline helped in improving depressive symptoms in patients with treatment-resistant depression with low-grade peripheral inflammation.
In a four-week randomised clinical MINDEP (MINocycline in DEPression) trial, 39 patients with major depressive disorder were recruited from services linked to South London and Maudsley NHS Foundation Trust (SLaM) and via public advertisement.