Page 20 - Madam Bass News Today : Breaking News, Live Updates & Top Stories | Vimarsana
Baker s VAX MANDATE — Parsing the Boston mayor s race PACs — LONG LINES for COVID TESTS return
politico.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from politico.com Daily Mail and Mail on Sunday newspapers.
North Korea counterfeit crackdown; Banksy trademarks criticised; MARQUES annual meeting update – news digest
worldtrademarkreview.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from worldtrademarkreview.com Daily Mail and Mail on Sunday newspapers.
Retroviral Elements Could Be Exploited to Fight Esophageal Cancer
Esophageal cancer, 3D illustration showing tumor on the wall of esophagus
May 10, 2021
Share
Endogenous retroviral elements (ERVs) the ancient viral DNA sequences that lurk in our genome have lost the ability to produce viral particles, but they can still cause mischief. For example, they can take part in the tangled mechanisms that give rise to cancer. However, in esophageal cancers associated with a cancer-promoting gene called SOX2, ERVs could make cancer cells more vulnerable to immunotherapy.
This possibility was recognized in a recent study led by Adam Bass, MD, a researcher at Columbia University. In this study, Bass and his colleagues created esophageal organoids from mouse tissue to follow the development of cancer from normal cells to malignancy. Using these organoids, the scientists found that a specific cancer-promoting gene in esophageal cancers called SOX2 leads to induction of expression of many ER
Esophageal cancers turn on ancient viral DNA hidden in our genome
Scientists have discovered that many esophageal cancers turn on ancient viral DNA that was embedded in our genome hundreds of millions of years ago. It was surprising, says Adam Bass, MD, the Herbert and Florence Irving Professor of Medicine at Columbia University Vagelos College of Physicians and Surgeons and Herbert Irving Comprehensive Cancer Center, who led the study published May 10 in
Nature Genetics. We weren t specifically searching for the viral elements, but the finding opens up a huge new array of potential cancer targets that I think will be extremely exciting as ways to enhance immunotherapy.
vimarsana © 2020. All Rights Reserved.