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Esophageal cancers turn on ancient viral DNA hidden in our genome
Scientists have discovered that many esophageal cancers turn on ancient viral DNA that was embedded in our genome hundreds of millions of years ago. It was surprising, says Adam Bass, MD, the Herbert and Florence Irving Professor of Medicine at Columbia University Vagelos College of Physicians and Surgeons and Herbert Irving Comprehensive Cancer Center, who led the study published May 10 in
Nature Genetics. We weren t specifically searching for the viral elements, but the finding opens up a huge new array of potential cancer targets that I think will be extremely exciting as ways to enhance immunotherapy.
A team of US researchers has conducted a novel cell study that reveals mechanisms which result in lethal Covid-19, and may explain long-term complications and show how Covid-19 differs from other infectious diseases.In patients who died of the .
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NEW YORK, NY (Jan. 11, 2021) Thousands of different genetic mutations have been implicated in cancer, but a new analysis of almost 10,000 patients found that regardless of the cancer s origin, tumors could be stratified in only 112 subtypes and that, within each subtype, the Master Regulator proteins that control the cancer s transcriptional state were virtually identical, independent of the specific genetic mutations of each patient.
The study, published Jan. 11 in
Cell, confirms that Master Regulators provide the molecular logic that integrates the effect of many different and patient-specific mutations to implement the transcriptional state of a specific tumor subtype, thus greatly expanding the fraction of patients who may respond to the same treatment.