In this application note, Yokogawa Fluid Imaging Technologies discusses the utility and growing use of flow imaging microscopy (FIM) in the characterization and quantification of particles in biotherapeutics. The technology has been used in a variety of studies, including those related to the identification of elevated particle concentrations associated with more severe adverse events and the development of AI-based techniques to identify protein aggregates. Researchers have also combined FlowCa
In this application note, Yokogawa discusses the use of Flow Imaging Microscopy (FIM) to analyze subvisible particles in biotherapeutic research. FIM instruments can measure particle characteristics like concentration, size, and morphology, but additional techniques are required to fully characterize the particle content of these samples. To address this, several FlowCam instruments have been developed that modify the basic FIM technique, such as FlowCam Nano and FlowCam LO. This white paper dem