In this application note, Yokogawa discusses the use of Flow Imaging Microscopy (FIM) to analyze subvisible particles in biotherapeutic research. FIM instruments can measure particle characteristics like concentration, size, and morphology, but additional techniques are required to fully characterize the particle content of these samples. To address this, several FlowCam instruments have been developed that modify the basic FIM technique, such as FlowCam Nano and FlowCam LO. This white paper dem
In this white paper, Yokogawa Fluid Imaging Technologies demonstrates the utility of FlowCam Nano in biotherapeutic development by analyzing solutions containing protein aggregates, sucrose aggregates, and E. coli cells using traditional subvisible and submicron FIM.