This article explores how you can measure particle size CQAs in (sterile) pharmaceutical packaging, and discusses non-invasive measurements using SR-DLS.
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Continuous Manufacturing of Liposomal Products
DIANT Phar
Image Credit: InProcess
Continuous manufacturing is starting to gain increased interest over traditional batch processing for nanoparticle drug delivery systems. DIANT Pharma Inc. (DIANT) provides a turnkey solution for the continuous processing of nanoparticles by offering multiple modules and integrated process analytical technology as a single closed-system.
Inventors of the Continuous Manufacturing System
DIANT is a startup co-founded by Antonio Costa, Ph.D. and Diane Burgess, Ph.D. In 2020, DIANT licensed their core manufacturing technology from UConn and was granted a patent on the technology earlier that year, with Burgess and Costa listed as inventors.
In drug development many applications are found for lipid-based nanoparticles (Lb-NPs) as successful transporters
for poorly water-soluble drugs and oligonucleotides in gene therapy.
Major advantages of lipids are their
high biocompatibility and biodegradability. In addition, advanced formulations using Lb-NP encapsulation of active ingredients can strongly contribute to targeted drug delivery in the body as well as stability and storage of the formulation.
The most important current medical applications include
cancer therapeutics and some of the current
COVID-19 vaccines.
Development and manufacturing of Lb-NP products often involves complex processes that need to be thoroughly understood and controlled to ensure optimum and constant quality of the medicine for patients. Therefore,