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Vigilant monitoring is needed to manage cardiac risks in patients using antipsychotics, doctors say
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Research Findings from Chang Gung Memorial Hospital Update Understanding of Information Technology (Long-term survival after major trauma: a retrospective nationwide cohort study from the National Health Insurance Research Database): Information Technology
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For the first time, fluoroquinolone exposure was tied to aortic complications in patients with established aortic disease in a large study.
In the cohort study from Taiwan, people with an existing aortic dissection (AD) or aortic aneurysm (AA) were at higher risk of adverse outcomes during the periods they were exposed to fluoroquinolones:
All-cause death: adjusted HR 1.61 (95% CI 1.50-1.73)
Aortic death: adjusted HR 1.80 (95% CI 1.50-2.15)
Aortic open surgery: adjusted HR 1.49 (95% CI 1.24-1.79)
Aortic stent placement: adjusted HR 1.64 (95% CI 1.30-2.06)
By contrast, amoxicillin (Amoxil) exposure was not associated with any of these outcomes over follow-up averaging 3.5 years, according to Shao-Wei Chen, MD, PhD, of Chang Gung Memorial Hospital, Linkou Medical Center, Chang Gung University, Taoyuan City, Taiwan, and colleagues.
March 08, 2021
Over the long term, patients who survive an aortic dissection appear to do just as well treated with either beta-blockers or ACE inhibitors/ARBs rather than other antihypertensive drugs, a retrospective analysis suggests.
Compared with other drug classes, beta-blockers and ACE inhibitors/ARBs each were associated with lower risks of all-cause hospital readmission and all-cause mortality over a span of up to 12 years, according to researchers led by Shao-Wei Chen, MD, PhD (Linkou Medical Center, Chang Gung University, Taoyuan City, Taiwan).
There were no differences for any outcomes which also included death due to aortic aneurysm or dissection, later aortic operation, major adverse cardiac and cerebrovascular events, and new-onset dialysis when those two medication groups were compared with each other.