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This Mutation May Be The Key Driver Of Human Aging

A study in Science has tied the aging process to the deterioration of tightly packaged bundles of cellular DNA known as heterochromatinand say that the genetic mutations underlying Werner syndrome, a disorder that leads to premature aging and death, results in the deterioration of these bundles.

United statesJuan carlos izpisua belmonteFuquan yangJiping yangRuijun baiFei yiEmi aizawaJingyi liXiaoyu liJunzhi zhouShunlei duanXiuling xuApril goeblHuize panKeiichiro suzukiYayu wang

Breast Cancer Cells Evade Immune Surveillance and Survive in Lymph Nodes: Study

Breast Cancer Cells Evade Immune Surveillance and Survive in Lymph Nodes: Study
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New yorkUnited statesPeigen huangAshwins kumarPatrik anderssonSampurna chatterjeeJessicam posadaDennis jonesCharlie chungJan willem van wijnbergenHengbo zhouIlgin erginLutz menzelSatoru moritaMeghanj omeliaSemir beyaz

Study sheds light on how breast cancer cells

Study sheds light on how breast cancer cells
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United statesNew yorkDennis jonesHengbo zhouLutz menzelMeghanj omeliaEthelr pereiraJan willem van wijnbergenPatrik anderssonTimothyp paderaZohreh amoozgarAshwins kumarIlgin erginCharlie chungSatoru moritaJessicam posada

Rice lab uncovers dynamics behind protein crucial in breast cancer

Rice lab uncovers dynamics behind protein crucial in breast cancer
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Carlos buenoShikai jinGaregin papoianPeter wolynesGustavo raskosky rice universityLeilay mathers charitable foundationUniversity of marylandProceedings of the national academy sciencesNational science foundationRice universityNational academyXun chenBullard welch foundation professorTheoretical biological physicsCritical assessmentProtein structure prediction

New CRISPR-based tool inserts large DNA sequences at desired sites in cells

Building on the CRISPR gene-editing system, MIT researchers designed a new tool that can snip out faulty genes and replace them with new ones. The new technique, PASTE, could hold promise for treating diseases that are caused by defective genes with a large number of mutations, such as cystic fibrosis.

United statesJonathan gootenbergEleonora ioannidiMatthew yarnallRohan krajeskiK lisa yangOmar abudayyehHocke tan centerCystic fibrosis foundation pioneer grantHarvey family foundationMcgovern institute neurotechnology programMcgovern institute for brain researchSwiss national science foundation postdoc mobility fellowshipUs national institutes of healthMcgovern instituteLeilay mathers charitable foundation