mRNA COVID-19 vaccination is immunogenic in the immunocompromised
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Research suggests patients who receive COVID-19 vaccines prior to a transplant and subsequent immunosuppression may be protected from the disease.
New research shows that vaccination against SARS-CoV-2 (the virus that causes COVID-19) in immunosuppressed individuals is immunogenic, though to a lesser extent than in the general population.
Two studies in thoracic organ transplantation published in the
Journal of Heart and Lung Transplantation (JHLT) provide the evidence for such a conclusion. Peled
et al. describes 77 vaccinated heart transplant recipients and Havlin
et al. (currently in review) presents 48 vaccinated lung transplant recipients.
Both studies assessed the immunogenicity of Pfizer and BioNTech’s messenger (m)RNA vaccine BNT162b2 mRNA (now marketed as Comirnaty
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ADDISON, Texas, May 13, 2021 /PRNewswire/ Evidence is emerging about the immunogenicity of vaccination to the SARS-CoV-2 virus in immune-suppressed individuals, including organ transplant recipients. The
Journal of Heart and Lung Transplantation (JHLT) presents two key studies in thoracic organ transplantation.
Peled et al describes 77 vaccinated heart transplant recipients, and Havlin et al presents 48 vaccinated lung transplant recipients. Both of these studies assessed the mRNA vaccine BNT162b2 mRNA (Pfizer/BioNTech). Vaccination was safe with no evidence of short-term allograft-related adverse effects in either cohort. The IgG vaccine-induced antibody response was lower in the transplant patients compared to that reported for the general population, especially in those heart and lung transplant recipients on anti-metabolite immune suppression that contained mycophenolic acid. Havlin et al specifically evaluated T- cell responses in lun
ISHLT s First All Virtual Annual Meeting to Kick off This Month
ISHLT2021 provides live and on-demand education for the advanced heart and lung failure community
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ADDISON, Texas, April 1, 2021 /PRNewswire/ The International Society of Heart and Lung Transplantation (ISHLT) will host its
41
st Annual Meeting & Scientific Sessions on 24-28 April, 2021. The all-virtual event will include educational content spanning the breadth of clinical practice and research concerning heart and lung transplantation, advanced heart and lung disease, mechanical circulatory support, and pulmonary vascular disease. The historic and inaugural virtual 41
st Annual Scientific Meeting of the ISHLT is just weeks away, says
More than 10 percent of children hospitalized with COVID-19 or multisystem inflammatory syndrome, an inflammatory condition commonly known as MIS-C that in rare cases has followed SARS-CoV-2 infection, experienced acute kidney injury, according to a study published March 3 in
Kidney International. Kids with kidney damage remained in the hospital an average of eight days longer than did other children facing these conditions without the added kidney stress.
“Recognizing that kidney function contributes to outcomes post-COVID is important to think about, especially in the pediatric population. These kids are young and have a whole life ahead of them,” says Abby Basalely, a pediatric nephrologist at Cohen Children’s Medical Center in New Hyde Park, New York, and a coauthor of the study.
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