mRNA COVID-19 vaccination is immunogenic in the immunocompromised
SHARES
Research suggests patients who receive COVID-19 vaccines prior to a transplant and subsequent immunosuppression may be protected from the disease.
New research shows that vaccination against SARS-CoV-2 (the virus that causes COVID-19) in immunosuppressed individuals is immunogenic, though to a lesser extent than in the general population.
Two studies in thoracic organ transplantation published in the
Journal of Heart and Lung Transplantation (JHLT) provide the evidence for such a conclusion. Peled
et al. describes 77 vaccinated heart transplant recipients and Havlin
et al. (currently in review) presents 48 vaccinated lung transplant recipients.
Both studies assessed the immunogenicity of Pfizer and BioNTech’s messenger (m)RNA vaccine BNT162b2 mRNA (now marketed as Comirnaty