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Kyoto University Graphical abstract The Kazuo Takayama lab shows how iPS cells can be used to study SARS-CoV-2 and COVID-19. With more than 125 million people infected and nearly 3 million dead, the COVID-19 pandemic has disrupted the world in inconceivable ways. Adding to the challenge is that the patient condition varies widely, from the asymptomatic to respiratory failure and death. A new study by CiRA researchers shows how iPS cells can be used to study infection by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), revealing gender differences seen with the disease. One of the devasting aspects of COVID-19 is its unpredictable nature. An unknown number of people infected are asymptomatic, and those that do show symptoms range widely, from mild to severe.

Emi sanoYukiko muramotoAyaka sakamotoTakuya yamamotoTakeshi nodaKazuo takayamaSayaka deguchiInstitute for frontier lifeInstitute for advanced study of human biologyPs cells teamKyoto universityJapan agency for medical researchTechnology agencyLaboratory of ultrastructural virologyJunior associate professor kazuo takayamaUltrastructural virology