New Giraffe genome sequencing tool reduces research bias cavalierdaily.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from cavalierdaily.com Daily Mail and Mail on Sunday newspapers.
Data from short-read sequencing up to a few hundred base pairs in length are computationally mapped to source locations and identities in a reference genome. However, the use of a single linear reference sequence generates bias in interpreting genetic variations. Scientists have now developed a new algorithmic tool they call Giraffe that can quickly and accurately map individual short sequencing reads to a pangenome reference representative of thousands of human genomes.