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Researchers speed identification of DNA regions that regulate gene expression
Corresponding author Yong Cheng, Ph.D., of the St. Jude Departments of Hematology and Computational Biology, helped develop a highly efficient method in identifying the genetic switches that regulate gene expression.
St. Jude Children’s Research Hospital scientists have developed an integrated, high-throughput system to better understand and possibly manipulate gene expression for treatment of disorders such as sickle cell disease and beta thalassemia. The research appears today in the journal Nature Genetics.
Researchers used the system to identify dozens of DNA regulatory elements that act together to orchestrate the switch from fetal to adult hemoglobin expression. The method can also be used to study other diseases that involve gene regulation.
‘I never give up’: Q&A with Chinese environmental lawyer Jingjing Zhang
Jingjing Zhang has been dubbed the “Erin Brockovich of China” for her work litigating against polluting companies on behalf of affected communities within the country.
Now living in the U.S., she has switched her focus to Chinese companies operating overseas, many of them under the aegis of Beijing’s ambitious and far-reaching Belt and Road Initiative.
But jurisdictional issues mean courts in China don’t yet hold Chinese companies accountable for their actions overseas.
In an interview with Mongabay founder Rhett A. Butler, Zhang talks about her career, what strategies could lead the Chinese government to establish regulations governing overseas investment, and the influence of government policy on Chinese companies.
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PHILADELPHIA - Heart attack, kidney failure, stroke. These are just a few of the life-threatening complications that patients are at risk for following surgery. Now Jefferson researchers have developed an easy-to-use, web-based tool that predicts the risk of post-surgical complications such as kidney failure and stroke. The model may help medical professionals put preventive measures in place before the need for emergency intervention. We need to be able to assess the risk of life-threatening, post-surgical complications so we can then come up with individualized ways to reduce those complications, says Sang Woo, MD, a clinical associate professor of medicine at Thomas Jefferson University who led the new research.
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Welcome to our Chinese Responsible Investment Overseas Newsletter. This newsletter aims to serve as a platform for updates, insights, and tools on key topics relating to social and environmental impacts of Chinese overseas investments and business, and as a resource to promote peer learning and informed decision-making. To provide more up-to-date information for practitioners and researchers in this field, we slightly upgrade the contents with lead story and practical resources in the past quarter, and guest blogs that present cutting edge issues and in-depth analysis of how to promote sustainable development and responsible business through Chinaâs Belt and Road Initiative (BRI) from leading experts & advanced organizations.