New Nanoparticle Platform Could Help Treat Various Neurological Disorders
Written by AZoNanoJan 4 2021
Over the last few decades, scientists have established the biological pathways that cause neurodegenerative diseases and have created potential molecular agents to target these pathways.
Yet, there has been a delay in translating these discoveries into clinically approved treatments, partially due to the challenges faced by researchers in delivering therapeutics into the brain through the blood-brain barrier (BBB).
To enable the successful delivery of therapeutic agents into the brain, a group of physicians, bioengineers, and colleagues from Brigham and Women’s Hospital and Boston Children’s Hospital developed a nanoparticle platform with the ability to facilitate therapeutically efficacious delivery of encapsulated agents in mice with an intact or physically breached BBB.
To treat brain disorder, scientists develop nanoparticle drug-delivery system
To treat brain disorder, scientists develop nanoparticle drug-delivery system
Last Updated: Sun, Jan 3rd, 2021, 07:48:05hrs
Washington [US], January 3 (ANI): To facilitate successful delivery of therapeutic agents to the brain, a team of bioengineers, physicians, and collaborators at Brigham and Women s Hospital and Boston Children s Hospital created a nanoparticle platform, which can facilitate therapeutically effective delivery of encapsulated agents in mice with a physically breached or intact the blood-brain barrier (BBB).
In the past few decades, researchers have identified biological pathways leading to neurodegenerative diseases and developed promising molecular agents to target them. However, the translation of these findings into clinically approved treatments has progressed at a much slower rate, in part because of the challenges scientists face in delivering therapeutics across the blood-brai
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Brigham City [US], January 2 (ANI): A study led by researchers of Brigham and Women's Hospital claims that technology could potentially offer a variety of treatments for human neurological disorders.
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Use of the delivery system in mouse models results in unprecedented siRNA penetration across the intact blood brain barrier
Technology could offer potential for a variety of human neurological disorders
In the past few decades, researchers have identified biological pathways leading to neurodegenerative diseases and developed promising molecular agents to target them. However, the translation of these findings into clinically approved treatments has progressed at a much slower rate, in part because of the challenges scientists face in delivering therapeutics across the blood-brain barrier (BBB) and into the brain. To facilitate successful delivery of therapeutic agents to the brain, a team of bioengineers, physicians, and collaborators at Brigham and Women s Hospital and Boston Children s Hospital created a nanoparticle platform, which can facilitate therapeutically effective delivery of encapsulated agents in mice with a physically breached or intact BBB. In a mouse mod