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The largest single cell study to date of the childhood cancer, neuroblastoma, has answered important questions about the genesis of the disease. The researchers from the Wellcome Sanger Institute, Great Ormond Street Hospital (GOSH) and the Princess Máxima Center for Pediatric Oncology, discovered that all neuroblastomas arise from a single type of embryonic cell called sympathoblasts.
The study, published today (5 February 2021) in Science Advances, sought to understand why neuroblastomas range in severity, with some easy to treat and others having relatively low five-year survival rates. The fact that all neuroblastomas arise from sympathoblasts makes them an attractive drug target, because these cells exist only in the tumour after the child is born.
Single Cell Type Identified as Neuroblastoma Target
February 8, 2021
Source: National Cancer Institute; photograph by Bill Branson
Through what they claim is the largest single cell study of neuroblastoma carried out to date, researchers from the Wellcome Sanger Institute, Great Ormond Street Hospital (GOSH), and the Princess Máxima Center for Pediatric Oncology, have found the answers to important questions about the genesis of this childhood cancer. Their results indicate that all neuroblastomas arise from a single type of embryonic cell, known as sympathoblasts, which could point to new therapeutic options. The discovery that all neuroblastomas arise from sympathoblasts makes these cells an attractive drug target, because they exist only in the tumor after the child is born.
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The largest single cell study to date of the childhood cancer, neuroblastoma, has answered important questions about the genesis of the disease. The researchers from the Wellcome Sanger Institute, Great Ormond Street Hospital (GOSH) and the Princess Máxima Center for Pediatric Oncology, discovered that all neuroblastomas arise from a single type of embryonic cell called sympathoblasts.
The study, published today (5 February 2021) in
Science Advances, sought to understand why neuroblastomas range in severity, with some easy to treat and others having relatively low five-year survival rates. The fact that all neuroblastomas arise from sympathoblasts makes them an attractive drug target, because these cells exist only in the tumour after the child is born.
Waikeria riot: Jail staff union s disgust as dust settles and clean-up bill looms
6 Jan, 2021 02:45 AM
7 minutes to read
The top jail has been completely destroyed and can no longer be used, Corrections Minister Kelvin Davis said. Video / Brett Phibbs / Mark Coote
The top jail has been completely destroyed and can no longer be used, Corrections Minister Kelvin Davis said. Video / Brett Phibbs / Mark Coote
The prison staff union leader says it s ludicrous to call six days of fiery destruction at Waikeria a protest .
And prison authorities say the Waikato jail has insurance but it s not yet known how much the damage will cost taxpayers.