Medicine
In memoriam: Louis Siminovitch, the father of genetic research in Canada Louis Siminovitch was the first chair of what is now U of T s department of molecular genetics and the founding director of Sinai Health s Lunenfeld-Tanenbaum Research Institute (photo by Dave Chan/Sinai Health Foundation)
The University of Toronto community is remembering University Professor
Louis Siminovitch, a scientific visionary who was the first chair of what is today the department of molecular genetics in the Temerty Faculty of Medicine.
Siminovitch, who was also the founding director of the Lunenfeld-Tanenbaum Research Institute (LTRI) at Sinai Health, died this week nearly one year after celebrating his 100th birthday, which took place as COVID-19 forced the world to physically distance and scientists stepped up to confront the challenge of a lethal new virus.
Legendary scientist Dr Louis Siminovitch shaped research in Canada
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Новости Днепра: Валентина Земцова оставили за решеткой пожизненно
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An international collaboration among researchers from Finland, Sweden, UK and the USA has captured ribosomes translating messenger RNA expressed from the maternally inherited mitochondrial genome. Utilising the latest advances in cryo-electron microscopy, the group discovered a novel mechanism that mitochondrial ribosomes use for the synthesis and delivery of newly made proteins to prevent premature misfolding. Disruptions to protein folding can lead to devastating human diseases.
There is a familiar saying, “It’s all in the genes”. As modern archaeology reveals, the DNA that encodes genes can be found among the remnants of our ancestors and from any organism, small and large, that once roamed the earth. The genetic blueprint alone is not sufficient; life requires the faithful expression and translation of our genomes. Basic research in molecular biology has revealed in beautiful detail the mechanisms by which these fundamental processes operate. One of these pioneering