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An international collaboration among researchers from Finland, Sweden, UK and the USA has captured ribosomes translating messenger RNA expressed from the maternally inherited mitochondrial genome. Utilising the latest advances in cryo-electron microscopy, the group discovered a novel mechanism that mitochondrial ribosomes use for the synthesis and delivery of newly made proteins to prevent premature misfolding. Disruptions to protein folding can lead to devastating human diseases.
There is a familiar saying, “It’s all in the genes”. As modern archaeology reveals, the DNA that encodes genes can be found among the remnants of our ancestors and from any organism, small and large, that once roamed the earth. The genetic blueprint alone is not sufficient; life requires the faithful expression and translation of our genomes. Basic research in molecular biology has revealed in beautiful detail the mechanisms by which these fundamental processes operate. One of these pioneering
Study reveals mechanism for translation of maternally inherited mitochondrial genome news-medical.net - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from news-medical.net Daily Mail and Mail on Sunday newspapers.
Credit: A. Amunts and D. Nowakowski
An international collaboration among researchers from Finland, Sweden, UK and the USA has captured ribosomes translating messenger RNA expressed from the maternally inherited mitochondrial genome. Utilising the latest advances in cryo-electron microscopy, the group discovered a novel mechanism that mitochondrial ribosomes use for the synthesis and delivery of newly made proteins to prevent premature misfolding. Disruptions to protein folding can lead to devastating human diseases.
There is a familiar saying, It s all in the genes . As modern archaeology reveals, the DNA that encodes genes can be found among the remnants of our ancestors and from any organism, small and large, that once roamed the earth. The genetic blueprint alone is not sufficient; life requires the faithful expression and translation of our genomes. Basic research in molecular biology has revealed in beautiful detail the mechanisms by which these fundamental processes oper