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How mRNA became a vaccine game-changer
22 minutes to read
By: David Crow
The molecule behind the Pfizer and Moderna jabs has turned the Covid tide. Can it revolutionise medicine? Not for the first time, Katalin Kariko was trying to convince a sceptic to take her scientific discoveries seriously. It was 2004, and she had spent about 15 years investigating messenger RNA, the genetic material that acts as a kind of courier in the human body, transporting recipes from our DNA to the part of the cell that produces proteins.
After countless false starts and wrong turns, she had made a breakthrough and wanted to file a patent. But to do so she had to win over an intellectual property officer at the University of Pennsylvania, where she then worked as a researcher. Their meeting was going badly. He was not very enthusiastic, he kept on asking, What s it good for? recalls Kariko. I was just so disappointed that he wasn t getting it.