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New England Journal of Medicine Publishes BRUIN Phase 1/2 Trial Data for Pirtobrutinib in BTK Inhibitor Pre-Treated Adult Patients with Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

New England Journal of Medicine Publishes BRUIN Phase 1/2 Trial Data for Pirtobrutinib in BTK Inhibitor Pre-Treated Adult Patients with Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
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United statesJoe fletcherKyle owensArthurg jamesDavid hymanJennifera woyachEli lillyExchange commissionAmerican society of hematologyRichardj solove research instituteLilly united statesLaboratory abnormalitiesOhio state university comprehensive cancer centerInternational workshop on chronic lymphocytic leukemiaNew england journalCancer hospital

Eli Lilly and Company Announces New England Journal of Medicine Publishes BRUIN Phase 1/2 Trial Data for Pirtobrutinib in BTK Inhibitor Pre-Treated Adult Patients with Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

Eli Lilly and Company announced that The New England Journal of Medicine published detailed results from the BRUIN Phase 1/2 trial evaluating the efficacy and safety of an investigational use of.

United statesEli lillyInternational workshop on chronic lymphocytic leukemiaAmerican society of hematologyNew england journalData publishedChronic lymphocytic leukemia

Data Show Promise of Pirtobrutinib in Treatment of CLL, SLL

Pirtobrutinib is a non–covalent (reversible) BTK inhibitor, demonstrating a 73.3% overall response rate with a median follow-up of 19.4 months among patients with chronic lymphocytic leukemia or small lymphocytic lymphoma.

United statesJennifer woyachEli lillyInternational workshop on chronic lymphocytic leukemiaAmerican society of hematology annual meetingRichardj solove research instituteNew england journalHematology annualChronic lymphocytic leukemia

Exposure of progressive immune dysfunction by SARS-CoV-2 mRNA vaccination in patients with chronic lymphocytic leukemia: A prospective cohort study

In a prospective cohort study, Kai Qin and colleagues investigate underlying mechanisms of immune dysfunction in CLL, by measuring humoral and cellular immune responses to SARS-CoV-2 mRNA vaccination in patients with varying degrees of disease progression.

United statesRockefeller universityNew yorkPaul bieniaszRickyw johnstoneTheodora hatziioannouPeter maccallum cancer centreInternational workshop on chronic lymphocytic leukemiaCancer immunobiology programSchool of medicine deanSevere acute respiratory syndrome coronavirusCreative commons attribution licenseMedicine deanImmunobiology programCoronavirus diseaseInternational workshop

Bristol Myers Squibb s Breyanzi (lisocabtagene maraleucel) is First and Only CAR T to Deliver Deep and Durable Efficacy in Pivotal Multicenter Trial in Relapsed or Refractory Chronic Lymphocytic Leukemia, Based on Data Presented at ASCO 2023

TRANSCEND CLL 004 is the first pivotal multicenter trial to evaluate a CAR T cell therapy in heavily pre-treated patients with relapsed or refractory chronic lymphocytic leukemia or small lymphocytic. | May 25, 2023

United statesBristol myers squibbAnne kerberTanya siddiqiDivision of lymphomaAmerican society of clinical oncologyInternational workshop on chronic lymphocytic leukemiaDrug administrationCity of hope national medical centerCell therapy developmentClinical oncologyAnnual meetingAssociate professorHope national medicalBristol myersMyers squibb