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FDA Lifts Partial Clinical Hold on Trial Evaluating NX-2127 in R/R B-Cell Malignancies

The FDA has lifted a partial clinical hold on a phase 1 trial evaluating NX-2127 in relapsed/refractory B-cell malignancies

Paulag oconnorInternational primary central nervous system lymphomaCollaborative groupInternational workshop on chronic lymphocytic leukemiaInternational working groupNurix therapeutics incNurix therapeuticsInternational workshopChronic lymphocytic leukemiaLugano classification

Advancing Treatment Selection in CLL Management

Treatment options are distinct in their mechanisms, safety profiles, and implications for patients’ quality of life.

United statesUnited kingdomEli lillyZanubrutinib brukinsaPirtobrutinib jaypircaInternational workshop on chronic lymphocytic leukemiaAlliance for clinical trials in oncologyLilly united statesGenentech incAstrazeneca pharmaceuticalsBeigene ltdExcella gmbh coAbbvie incAmerican society of clinical oncology annual meetingInternational workshopChronic lymphocytic leukemia

Ibrutinib Plus Venetoclax With MRD-Directed Duration of Treatment Is a New Standard-of-Care Regimen for Previously Unmanaged CLL

The MRD-guided treatment approach has a significant advantage over chemotherapy.

United kingdomUnited statesSan diegoLeeds teaching hospitals national health serviceInternational workshop on chronic lymphocytic leukemiaUniversity of leedsAmerican society of hematology annual meeting expositionJanssen biotechPeter hillmenAmerican societyHematology annual meetingInternational workshopChronic lymphocytic leukemia

New Gold Standard for Previously Untreated CLL

Personalized, time-limited regimen of venetoclax plus ibrutinib improves survival versus FCR

United statesUnited kingdomMikkael sekeresUk national cancer research instituteAmerican society of hematologyUniversity of miami miller school medicineInternational workshop on chronic lymphocytic leukemiaJames university hospital in leedsPeter hillmenUniversity hospitalAmerican societyMiami miller schoolCancer research instituteInternational workshopChronic lymphocytic leukemiaManaging editor

Ibrutinib Plus Venetoclax With MRD-Directed Duration of Treatment Is a New Standard of Care Regimen for Previously Untreated CLL

This is the first trial to show that a MRD-guided approach with treatment beyond MRD negativity has a significant advantage over chemotherapy, both in terms of PFS and OS.

United kingdomUnited statesAmerican society of hematologyUniversity of leedsInternational workshop on chronic lymphocytic leukemiaPeter hillmenAmerican societyAnnual meetingLeeds teaching hospitalsInternational workshopChronic lymphocytic leukemiaBinet stage

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