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Study highlights an immunological mechanism underlying Long COVID

SARS-CoV-2 triggers the production of the antiviral protein IFN-γ, which is associated with fatigue, muscle ache and depression.

United kingdomNyarie sitholeBenjamin krishnaUniversity of cambridgeUniversity of cambridge deptCambridge institute of therapeutic immunology infectious diseaseScience advancesCambridge instituteTherapeutic immunologyInfectious diseaseRoyal papworth hospitalCovid 19Immune systemArs cov 2T cell

Study suggests patients with severe long COVID present with variable symptoms, do not cluster in relation to organs affected or immunological states

A new preprint reports significantly associated findings that may help predict severe long COVID and understand what causes it.

Anucha naisuntorn shutterstockMultisystem inflammatory syndromeCovid 19Immune responseArs cov 2

Targeting T-Cell–Based Therapies to Treat Alopecia Areata

New research explores T cells and their signaling pathways in alopecia areata (AA), highlighting promising drug targets for future treatment.

Image creditAlopecia areataJanus kinase inhibitorsJak inhibitorsT cellsHair folliclesHepatocellular carcinomaImmune privilegeSignal transducers and activators of transcriptionChemokine ligandLymphocyte specific protein tyrosine kinaseZeta chain associated protein kinaseFunctional affinity

Cytokine interferon-gamma can be a disease-modifying therapeutic target in multiple system atrophy

Multiple system atrophy is a rare and fatal neurodegenerative disease, where insoluble inclusions of the protein alpha-synuclein appear in oligodendrocyte cells of the brain.

United statesNikhita mudiumNicolej corbin steinActa neuropathologicaJeffreyh kordowerJhodim websterFredricp manfredssonAsta zaneRajesh guptaGabriellem childersActa neuropathologica communicationsDepartment of neurologyBarrow neurological instituteArizona state universityNational institutes of healthUniversity of alabama at birmingham

Circulatory cholesterol levels are inversely linked to mortality of patients with sepsis and critical illness

The association between biomarkers of cholesterol homeostasis and mortality in critically ill patients.

Surfsup shutterstockOvid medlineHealth literatureCumulative indexAllied health literatureCochrane central registerControlled trialsOttawa scaleCritical careIntensive care

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