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Cytokine interferon-gamma can be a disease-modifying therapeutic target in multiple system atrophy

Multiple system atrophy is a rare and fatal neurodegenerative disease, where insoluble inclusions of the protein alpha-synuclein appear in oligodendrocyte cells of the brain.

United statesNikhita mudiumNicolej corbin steinActa neuropathologicaJeffreyh kordowerJhodim websterFredricp manfredssonAsta zaneRajesh guptaGabriellem childersActa neuropathologica communicationsDepartment of neurologyBarrow neurological instituteArizona state universityNational institutes of healthUniversity of alabama at birmingham

Interferon-gamma drives brain pathology in a mouse model of multiple system atrophy

Interferon-gamma drives brain pathology in a mouse model of multiple system atrophy
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Nicolej corbin steinActa neuropathologicaUniversity of alabama at birminghamActa neuropathologica communicationsDepartment of neurologyAshley harms