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The psychedelic compound found in magic mushrooms may be at least as effective as a leading antidepressant medication in a therapeutic setting, a new study suggests. Researchers compared the therapeutic potential of psilocybin – found in the mushrooms – with a six-week course of the antidepressant escitalopram in 59 people with moderate to severe depression. They found that, while depression scores were reduced in both groups, the reductions occurred more quickly in the psilocybin group and were greater in magnitude. However, they warned that the main comparison between psilocybin and the antidepressant was not statistically significant. They said larger trials with more patients over a longer period are needed to show if the compound can perform as well as, or more effectively than, an established antidepressant.

City ofUnited kingdomAnthony cleareRobin carhart harrisDavid nuttEdmondj safraKing college londonInstitute of psychiatry psychologyNeuropsychopharmacology at imperial college londonPsychedelic researchImperial college londonEdmondj safra chairNew england journalCompass pathwaysItem quick inventoryDepressive symptomatology