Jul 8, 2021
dbGENVOC is a browsable online database of GENomic Variants of Oral Cancer and is a free resource. First release of dbGENVOC contains (i) ~24 million somatic and germline variants derived from whole exome sequences of 100 Indian oral cancer patients and whole genome sequences of 5 oral cancer patients from India, (ii) somatic variation data from 220 patient samples drawn from the USA and analyzed by TCGA-HNSCC project and (iii) manually curated variation data of 118 patients from recently published peer-reviewed publications. Variants were identified by the community approved best practice protocol and annotated using multiple analytic pipeline.
dbGENVOC is not just a catalogue of genomic variants, it has a built-in powerful search engine. It also allows a reasonable extent of statistical and bioinformatic analysis to be carried out online, including identifying variants in associated altered pathways in oral cancer.
Express News Service
BENGALURU: The new SARS-CoV-2 virus variant discovered in the United Kingdom and which has slipped into India has people worried in Karnataka. That is understandable as ten Covid-19-positive patients have been detected in Karnataka, the highest in the country. Of these, six are in Bengaluru (three in Bommanahalli, two in Rajajinagar and one in JP Nagar), while four are in Shivamogga.
The UK variant also referred to as “SARS-CoV-2 VOC 202012/01” (the first ‘Variant Of Concern’ from 2020 December), or “B.1.1.7” was identified early December by UK health officials through genome sequencing of two samples collected on September 20. The tests, confirming the new variant, estimated it to have up to 70 per cent higher transmissibility than its original version.
Centre identifies 10 regional laboratories for genome sequencing to detect new COVID variant
The emergence of the new coronavirus strain in the UK has required India to increase viral genomic surveillance in order to understand the spread of the virus in a rapid and robust manner.
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NEW DELHI:
Ten regional laboratories have been identified by the Centre where states will send five per cent of their COVID-19 positive samples for genome sequencing to detect the new coronavirus variant that has emerged in the United Kingdom recently.
The health ministry has also established the Indian SARS-CoV-2 Genomics Consortium (INSACOG) for laboratory and epidemiological surveillance and expand whole genome sequencing of the coronavirus in the country, aiding in the understanding of how the virus spreads and evolves.