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Three-way interaction found between HLA-B27, male sex, sacroiliitis development in IBD

CHICAGO — In patients with inflammatory bowel disease, a “strong and consistent three-way interaction” was identified between HLA-B27, male sex and the development of sacroiliitis, according to data presented at Digestive Disease Week.Sacroiliitis occurs in approximately 20% of patients with IBD, often aligned with male sex and HLA-B27 status; however, large-scale studies on the

How Fat Burden May Affect IBD Drug Dosing

Target levels of infliximab in patients with IBD and high visceral adipose fat burden may be higher, suggesting the potential need to personalize dosing strategies.

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