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Gefapixant yields modest improvements in refractory, unexplained chronic cough vs placebo

Gefapixant yields modest improvements in refractory, unexplained chronic cough vs placebo
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J mark madisonRichards irwinMcmaster universityEuropean respiratory society international congressUmass chan medical schoolImran satiaCochrane central registerControlled trialsLeicester cough questionnaireChan medical school

Efficacy and Tolerability of Gefapixant for Treatment of Refractory or Unexplained Chronic Cough: A Systematic Review and Dose-Response Meta-Analysis | Otolaryngology | JAMA

This systematic review and dose-response meta-analysis evaluates the efficacy and tolerability of gefapixant, a new P2X3 antagonist, for the treatment of adults

United statesEj moran campbellCochrane roEuropean respiratory societyEuropean medicines agencyDepartment of medicineBellus healthCochrane bias methods groupFaculty of health sciencesAmerican academy of allergyMcmaster university medical centreCanadian lung associationMcmaster universityCanadian institutes of health researchAmerican college of chest physiciansDrug administration

Chronic Cough Drug Shows Some Benefit, but Taste-Related Events an Issue

Meta-analysis found mixed results for a drug that's about to go before an FDA panel

United statesJ mark madisonElena kumMadison jm gefapixantRichards irwinEuropean respiratory societyMcmaster universityLeicester cough questionnaireImran satiaMassachusetts chan medical school

Canadian university set for Phase 2 trials of inhaled COVID vaccine

COVID researchers at McMaster University in Canada received $8.2 million from the Canadian Institutes of Health Research (CIHR).

Mathew millerKaren mossmanZhou xingMark loebBrian lichtyCanada researchInfectious diseases researchFiona smaillGlobal nexusBiological threatsGroote instituteInfectious diseaseCanada research chairInfectious diseasesImran satia

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