Kyushu University researchers find that one of the causes of CKD induced heart failures is the over expression of G protein-coupled receptor 68 in monocytes. Monocyte disruption was caused by the activation of the Clock gene, the key regulator of circadian rhythm via the increased level of vitamin A in the body resulting from kidney dysfunction.
The reluctance or refusal to accept COVID-19 vaccinations can be tackled by a five-pronged strategy to addressing the behavioral and socio-demographic factors behind vaccine hesitancy. Writing in the Journal of the Royal Society of Medicine, a group of population health, demographic, epidemiology and behavioral scientists propose an approach focused on confidence, complacency, convenience, communication and context.
New research into Alzheimer s disease (AD) suggests that secondary infections and new inflammatory events amplify the brain s immune response and affect memory in mice and in humans even when these secondary events occur outside the brain.
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IMAGE: A researcher at Calibr, the drug discovery division of Scripps Research, working in the high-throughput screening facility used to identify potential COVID-19 therapies. view more
Credit: Scripps Research
June 3, 2021 - LA JOLLA, CA Mining the world s most comprehensive drug repurposing collection for COVID-19 therapies, scientists have identified 90 existing drugs or drug candidates with antiviral activity against the coronavirus that s driving the ongoing global pandemic.
Among those compounds, the Scripps Research study identified four clinically approved drugs and nine compounds in other stages of development with strong potential to be repurposed as oral drugs for COVID-19, according to results published June 3 in the journal
Alzheimer s & Dementia: The Journal of the Alzheimer s Association. We found that all causes of dementia are risk factors for severity and death in COVID-19 and that these risks are more pronounced for Alzheimer s patients,
Sérgio Verjovski-Almeida, principal investigator for the project and a professor at USP s Chemistry Institute, told
Agência FAPESP.
Dementia had already been identified as a risk factor for COVID-19, alongside other comorbidities, such as cardiovascular and respiratory diseases, high blood pressure, diabetes, obesity, and cancer. One of the reasons is age: patients with dementia tend to be older, and many live in care homes where the risks of infection and viral transmission are greater.