1Department of Neurosurgery, The Affiliated Hospital of Southwest Medical University, Luzhou, China
2Luzhou Key Laboratory of Neurological Diseases and Brain Function, The Affiliated Hospital of Southwest Medical University, Luzhou, China
3Academician (Expert) Workstation of Sichuan Province, The Affiliated Hospital of Southwest Medical University, Luzhou, China
4Sichuan Clinical Research Center for Neurosurgery, The Affiliated Hospital of Southwest Medical University, Luzhou, China
Subarachnoid hemorrhage (SAH) is a devastating form of stroke, which poses a series of intractable challenges to clinical practice. Imbalance of mitochondrial homeostasis has been thought to be the crucial pathomechanism in early brain injury (EBI) cascade after SAH. Irisin, a protein related to metabolism and mitochondrial homeostasis, has been reported to play pivotal roles in post-stroke neuroprotection. However, whether this myokine can exert neuroprotection effects after SAH remains unknown. In t
G), invasion rate (
H,
I) in vitro model of LNCap cell. p 0.01 compared with negative group, #p 0.01 compared with down-regulation of RAMS11 group.
Abbreviations: Negative, negative mimics group; SiRAMS11, down-regulation of RAMS11 group; Top2α, over-expression of Top2α group.
Discussion
The treatment of prostate cancer is mainly determined by objective factors, including patient age, physical condition, clinical stage, Gleason score, presence or absence of pelvic lymph nodes, distant metastases, and life expectancy.
18 At present, there are various therapeutic methods for prostate cancer, each with advantages and disadvantages.
19 Comprehensive consideration should be given towards patients with early-stage prostate cancer according to the patient’s condition. While patients with advanced prostate cancer still cannot be cured, the treatment should aim to relieve clinical symptoms and to prolong survival.