G), invasion rate (
H,
I) in vitro model of LNCap cell. p 0.01 compared with negative group, #p 0.01 compared with down-regulation of RAMS11 group.
Abbreviations: Negative, negative mimics group; SiRAMS11, down-regulation of RAMS11 group; Top2α, over-expression of Top2α group.
Discussion
The treatment of prostate cancer is mainly determined by objective factors, including patient age, physical condition, clinical stage, Gleason score, presence or absence of pelvic lymph nodes, distant metastases, and life expectancy.
18 At present, there are various therapeutic methods for prostate cancer, each with advantages and disadvantages.
19 Comprehensive consideration should be given towards patients with early-stage prostate cancer according to the patient’s condition. While patients with advanced prostate cancer still cannot be cured, the treatment should aim to relieve clinical symptoms and to prolong survival.