Getting under skin of an autoimmune disorder miragenews.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from miragenews.com Daily Mail and Mail on Sunday newspapers.
E-Mail
CRISPR technology allows researchers to edit genomes by altering DNA sequences and by thus modifying gene function. Its many potential applications include correcting genetic defects, treating and preventing the spread of diseases and improving crops.
Genome editing tools, such as the CRISPR-Cas9 technology, can be engineered to make extremely well-defined alterations to the intended target on a chromosome where a particular gene or functional element is located. However, one potential complication is that CRISPR editing may lead to other, unintended, genomic changes. These are known as off-target activity. When targeting several different sites in the genome off target activity can lead to translocations, unusual rearrangement of chromosomes, as well as to other unintended genomic modifications.
New immune players involved in metabolic liver disease eurekalert.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from eurekalert.org Daily Mail and Mail on Sunday newspapers.
Share
Multiple myeloma (a type of blood cancer) patients live much longer today than in the past, thanks to new targeted anti-myeloma drugs, but ultimately most develop resistance to the medications, and in some the disease is resistant to therapy from the start. Weizmann Institute of Science researchers, in collaboration with physicians from
Tel Aviv Sourasky Medical Center (TASMC), have made use of extremely sensitive genomic technology to reveal genetic pathways that characterize some of the more resistant cases of multiple myeloma.
Nature Medicine, may lead to a more informed, personalized treatment for these patients, and it paves the way to using this new technology for discovering additional disease targets in other cancers.